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dc.contributor.authorRahab W Kamau, Veronica M Masila, Jacob O Midiwo, Quintino A Mgani, Mallika Kumarihamy, Mei Wang, Jianping Zhao, Ilias Muhammad
dc.date.accessioned2022-06-22T09:19:03Z
dc.date.available2022-06-22T09:19:03Z
dc.date.issued2022
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/5288
dc.descriptionTo link to this article: https://doi.org/10.1080/14786419.2022.2062349en_US
dc.description.abstractA new 3,800-flavanone-flavonol dimer gnidiflavanone-flavonol (1) and 10 known compounds (2–11), including four rare primula type flavones 2–5, were isolated from the roots of Gnidia apicu lata. Compounds 2–5 and 7 were reported for the first time from the plant family Thymelaeceae. Structures of the isolated com pounds were established by spectroscopic data, including 1D and 2D NMR (COSY, HMBC, HSQC and ROESY) and mass spectrometry, as well as by the comparison with literature data. The crude roots extract and isolated compounds were evaluated for antimicrobial and antiplasmodial activities. Among isolated compounds, 6- hydroxyflavone (4) and 6-O-acetylflavone (4a) showed antiplasmo dial activity against chloroquine-sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparumen_US
dc.publisherTaylor & Francisen_US
dc.subjectGnidia apiculata; 3,800- flavanone-flavonol dimer; gnidiflavanone-flavonol; primula-type flavones; antiplasmodialen_US
dc.titleA new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculataen_US
dc.typeArticleen_US


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