| dc.contributor.author | Veronica M Masila, Albert J Ndakala, Jacob O Midiwo, Robert Byamukama, Rahab W Kamau, Mallika Kumarihamy, Ilias Muhammad | |
| dc.date.accessioned | 2022-06-22T09:09:11Z | |
| dc.date.available | 2022-06-22T09:09:11Z | |
| dc.date.issued | 2022-05-03 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/5287 | |
| dc.description | To link to this article: https://doi.org/10.1080/14786419.2020.1833201 | en_US |
| dc.description.abstract | Monoterpene derivatives are of great biological relevance in the
pharmaceutical industry. In the present study, pyrrolidine deriva tive of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected
monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone
(3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzy loxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2),
2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4),
cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was
determined based on NMR and HRMS spectral data. Compound 4
exhibited activity against fungi Cryptococcus neoformans with an
IC50 value of < 0.8 mg/mL. In addition, this compound 4 had an
IC50 value of 14.97 mg/mL against methicillin resistant
Staphylococcus aureus bacteria. Previous to the current study,
both compound 6 and 7 had been reported to have anti-micro bial and anti-fungal activities | en_US |
| dc.publisher | Taylor & Francis | en_US |
| dc.subject | Monoterpenes; 2-Isopropyl 5-methyl-3,6-dioxocyclo hexa-1,4-dien-1-yl acetate; Carvacrol; Cis-3- hydroxypiperitone; Anti MRSA; Anti-cryptococc | en_US |
| dc.title | Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties | en_US |
| dc.type | Article | en_US |
