| dc.description.abstract | The plant species Elaeodendron buchananii Loes is widely used in
folklore medicine to manage microbial infections in Kenya. Previous
studies on the plant fruits and root bark revealed the presence of
steroids and terpenoids. The present phytochemical analysis of
the plant stem bark has led to the isolation of four new triterpenes
characterized as methyl 3β-acetoxy-11α, 19α, 28-trihydroxyurs-12-
en-23-oic acid (1), 3β, 11α, 19α-trihydroxyurs-12-en-23, 28-dioic acid
(2), 3β-acetoxy-19α, 23, 28-trihydroxyurs-12-ene (3) and 3-oxo-19α,
28-dihydroxyurs-12-en-24-oic acid (4), together with ten known
ones (5–14), whose structures were elucidated using spectroscopic
techniques. The isolate canophyllol (8) showed promising antibacterial
activity against N. meningitides with MIC value of 31.25 μg/ml. | en_US |
