| dc.contributor.author | Dorothy A Okoth, Joachim J Hug, Ronald Garcia, Cathrin Spröer, Jörg Overmann, Rolf Müller | |
| dc.date.accessioned | 2021-05-19T12:36:47Z | |
| dc.date.available | 2021-05-19T12:36:47Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/3765 | |
| dc.description.abstract | Myxobacteria represent an under-investigated source for biologically active natural products featuring intriguing structural moieties with potential applications, e.g., in the pharmaceutical industry. Sorangiadenosine and the here-discovered 2-hydroxysorangiadenosine are myxobacterial sesquiterpene–nucleosides with an unusual structural moiety, a bicyclic eudesmane-type sesquiterpene. As the biosynthesis of these rare terpene–nucleoside hybrid natural products remains elusive, we investigated secondary metabolomes and genomes of several 2-hydroxysorangiadenosine-producing myxobacteria. We report the isolation and full structure elucidation of 2-hydroxysorangiadenosine and its cytotoxic and antibiotic activities and propose a biosynthetic pathway in the myxobacterium Vitiosangium cumulatum MCy10943 | en_US |
| dc.publisher | Multidisciplinary Digital Publishing Institute | en_US |
| dc.subject | myxobacteria; terpene–nucleoside; biosynthesis; antibiotics; sorangiadenosine; 2-hydroxysorangiadenosine; secondary metabolites; genome-mining; antibiotics; natural products discovery | en_US |
| dc.title | 2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene–Nucleoside | en_US |
| dc.type | Article | en_US |
